Polymer Cancerostatics Targeted by Recombinant Antibody Fragments to GD2-Positive Tumor Cells.

  title={Polymer Cancerostatics Targeted by Recombinant Antibody Fragments to GD2-Positive Tumor Cells.},
  author={Robert Pola and Vlastimil Kr{\'a}l and Sergey K. Filippov and Leonid I Kaberov and Tom{\'a}{\vs} Etrych and Irena Sieglov{\'a} and Juraj Sedl{\'a}{\vc}ek and Milan F{\'a}bry and Michal Pechar},
  volume={20 1},
A water-soluble polymer cancerostatic actively targeted against cancer cells expressing a disialoganglioside antigen GD2 was designed, synthesized and characterized. A polymer conjugate of an antitumor drug doxorubicin with a N-(2-hydroxypropyl)methacrylamide-based copolymer was specifically targeted against GD2 antigen-positive tumor cells using a recombinant single chain fragment (scFv) of an anti-GD2 monoclonal antibody. The targeting protein ligand was attached to the polymer-drug conjugate… 

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