Polyketide synthesis: prospects for hybrid antibiotics.

  title={Polyketide synthesis: prospects for hybrid antibiotics.},
  author={Leonard Katz and Stefano Donadio},
  journal={Annual review of microbiology},
Polyketides fall into two structural classes: aromatic and complex. The former are built mainly from acetate units through a reiterative process wherein the beta-carbonyl groups formed after each condensation cycle are left largely unreduced. Complex polyketides are composed of acetates, propionates, or butyrates, and the extent of beta-carbonyl reduction varies from one cycle to the next. Two themes for polyketide synthases are emerging. Aromatic PKSs are determined by four to six genes… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
74 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 74 extracted citations

Similar Papers

Loading similar papers…