Polyketide synthesis: prospects for hybrid antibiotics.

@article{Katz1993PolyketideSP,
  title={Polyketide synthesis: prospects for hybrid antibiotics.},
  author={Leonard Katz and Stefano Donadio},
  journal={Annual review of microbiology},
  year={1993},
  volume={47},
  pages={875-912}
}
Polyketides fall into two structural classes: aromatic and complex. The former are built mainly from acetate units through a reiterative process wherein the beta-carbonyl groups formed after each condensation cycle are left largely unreduced. Complex polyketides are composed of acetates, propionates, or butyrates, and the extent of beta-carbonyl reduction varies from one cycle to the next. Two themes for polyketide synthases are emerging. Aromatic PKSs are determined by four to six genes… CONTINUE READING

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