Polyketide synthase gene responsible for citrinin biosynthesis in Monascus purpureus.

  title={Polyketide synthase gene responsible for citrinin biosynthesis in Monascus purpureus.},
  author={Takeo Shimizu and Hiroshi Kinoshita and Shinji Ishihara and Kanae Sakai and Shiro Nagai and Takuya Nihira},
  journal={Applied and environmental microbiology},
  volume={71 7},
Citrinin produced by Aspergillus, Penicillium, and Monascus species is a polyketide compound that has nephrotoxic activity in mammals and is bactericidal toward gram-positive bacteria. To avoid the risk of citrinin contamination in other fermentation products produced by Monascus purpureus, knowledge of the citrinin biosynthetic genes is needed so that citrinin-nonproducing strains can be generated. We cloned a polyketide synthase (PKS) gene from M. purpureus with degenerate primers designed to… CONTINUE READING
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