Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics.

@article{Hutchinson1995PolyketideSG,
  title={Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics.},
  author={C. Richard Hutchinson and Isao Fujii},
  journal={Annual review of microbiology},
  year={1995},
  volume={49},
  pages={201-38}
}
Polyketides are produced primarily in microorganisms through a specialized metabolism that is a variation of fatty acid biosynthesis. A strong sequence and mechanistic similarity among many of the fatty acid and polyketide synthase enzymes has led to two paradigms for explaining polyketide biochemistry. In one, polyketides are formed by enzyme complexes consisting of four to seven monofunctional proteins in which the beta-carbonyl groups of the intermediates resulting from the condensation of… CONTINUE READING

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