Polyketide and Nonribosomal Peptide Antibiotics: Modularity and Versatility

  title={Polyketide and Nonribosomal Peptide Antibiotics: Modularity and Versatility},
  author={C. Walsh},
  pages={1805 - 1810}
  • C. Walsh
  • Published 2004
  • Biology, Medicine
  • Science
  • Polyketide (PK) and nonribosomal peptides (NRP), constructed on multimodular enzymatic assembly lines, often attain the conformations that establish biological activity by cyclization constraints introduced by tailoring enzymes. The dedicated tailoring enzymes are encoded by genes clustered with the assembly line genes for coordinated regulation. NRP heterocyclizations to thiazoles and oxazoles can occur on the elongating framework of acyl-S enzyme intermediates, whereas tandem cyclic PK… CONTINUE READING
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