Polyisoprene matrix for progesterone release: in vitro and in vivo studies.

  title={Polyisoprene matrix for progesterone release: in vitro and in vivo studies.},
  author={Valeria Heredia and Ismael D Bianco and Humberto Tr{\'i}bulo and Ricardo Tr{\'i}bulo and M Ferro Seoane and Sonia Faudone and S{\'i}lvia Lucia Cuffini and N A Demichelis and H Schalliol and Dante Miguel Beltramo},
  journal={International journal of pharmaceutics},
  volume={382 1-2},
Latex, a polyisoprene (PI) hydrophobic elastomer, was evaluated in vitro and in vivo as a matrix for intravaginal steroid hormone delivery. Matrices containing hormone were prepared by swelling latex in chloroform that contained soluble progesterone (P4). In vitro studies demonstrate that P4 release from PI follows a zero order model during at least 100 h and depends on initial load up to 10 mg cm(-2). The release of P4 from a PI matrix was found to be two times faster than from a… CONTINUE READING