Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages.

@article{Haisma2008PolyinosinicAE,
  title={Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages.},
  author={Hidde J. Haisma and Jan A A M Kamps and Gera K Kamps and Jos{\'e}e A. Plantinga and Marianne G Rots and Anna Rita Bellu},
  journal={The Journal of general virology},
  year={2008},
  volume={89 Pt 5},
  pages={1097-105}
}
Adenovirus is among the preferred vectors for gene therapy because of its superior in vivo gene-transfer efficiency. However, upon systemic administration, adenovirus is preferentially sequestered by the liver, resulting in reduced adenovirus-mediated transgene expression in targeted tissues. In the liver, Kupffer cells are responsible for adenovirus degradation and contribute to the inflammatory response. As scavenger receptors present on Kupffer cells are responsible for the elimination of… CONTINUE READING

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