Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages.

  title={Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages.},
  author={Hidde J. Haisma and Jan A A M Kamps and Gera K Kamps and Jos{\'e}e A. Plantinga and Marianne G Rots and Anna Rita Bellu},
  journal={The Journal of general virology},
  volume={89 Pt 5},
Adenovirus is among the preferred vectors for gene therapy because of its superior in vivo gene-transfer efficiency. However, upon systemic administration, adenovirus is preferentially sequestered by the liver, resulting in reduced adenovirus-mediated transgene expression in targeted tissues. In the liver, Kupffer cells are responsible for adenovirus degradation and contribute to the inflammatory response. As scavenger receptors present on Kupffer cells are responsible for the elimination of… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 27 extracted citations

"Evolving nanoparticle gene delivery vectors for the liver: What has been learned in 30 years".

Journal of controlled release : official journal of the Controlled Release Society • 2015
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 72 references

Is the class A macrophage scavenger receptor (SR-A) multifunctional? - The mouse's tale.

The Journal of clinical investigation • 2001
View 3 Excerpts
Highly Influenced

Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver.

Molecular therapy : the journal of the American Society of Gene Therapy • 2001
View 4 Excerpts
Highly Influenced

HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses.

Proceedings of the National Academy of Sciences of the United States of America • 1997
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…