Polyhydroxyethylaspartamide-based micelles for ocular drug delivery.

  title={Polyhydroxyethylaspartamide-based micelles for ocular drug delivery.},
  author={Claudine Civiale and Mariano Licciardi and Gennara Cavallaro and Gaetano Giammona and Maria Grazia Mazzone},
  journal={International journal of pharmaceutics},
  volume={378 1-2},
In this paper three copolymers of polyhydroxyethylaspartamide (PHEA), bearing in the side chains polyethylene glycol (PEG) and/or hexadecylamine (C(16)) (PHEA-PEG, PHEA-PEG-C(16) and PHEA-C(16) respectively) have been studied as potential colloidal drug carriers for ocular drug delivery. The physical characterization of all three PHEA derivatives, using the Langmuir trough (LT) and micellar affinity capillary electrophoresis (MACE) techniques allowed to assume that whereas alone PHEA backbone… CONTINUE READING
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