Polyguanosine motif increases cellular oligonucleotide uptake in the brain cortex.

@article{Zhang2006PolyguanosineMI,
  title={Polyguanosine motif increases cellular oligonucleotide uptake in the brain cortex.},
  author={Zhiren Zhang and Uwe Fauser and Hermann Josef Schluesener},
  journal={Neuroreport},
  year={2006},
  volume={17 15},
  pages={1579-83}
}
Cellular uptake and localization of fluorescein isothiocyanate-labelled or biotin-labelled CpG-oligonucleotides (oligonucleotides containing unmethylated CpG dinucleotides within specific flanking bases) with or without 3'-end continuous guanosines (polyG motif) were studied in the rat cortex. Twenty minutes after intracerebral microinjection, labelled CpG… CONTINUE READING