Polyglycylation of tubulin: a posttranslational modification in axonemal microtubules.

@article{Redeker1994PolyglycylationOT,
  title={Polyglycylation of tubulin: a posttranslational modification in axonemal microtubules.},
  author={Virginie Redeker and Nicolette Levilliers and Jean Marie Schmitter and Jean Pierre Le Caer and Jean Rossier and A Adoutte and M. H. Br{\'e}},
  journal={Science},
  year={1994},
  volume={266 5191},
  pages={1688-91}
}
A posttranslational modification was detected in the carboxyl-terminal region of axonemal tubulin from Paramecium. Tubulin carboxyl-terminal peptides were isolated and analyzed by Edman degradation sequencing, mass spectrometry, and amino acid analysis. All of the peptides, derived from both alpha and beta tubulin subunits, were modified by polyglycylation, containing up to 34 glycyl units covalently bound to the gamma carboxyl group of glutamyl residues. This modification, present in one of… CONTINUE READING

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