Polyglutamine tracts: no evidence of a major role in bipolar disorder

  title={Polyglutamine tracts: no evidence of a major role in bipolar disorder},
  author={Gustavo Turecki and Martin Alda and Paul Grof and Ridha Joober and Patrizia Cavazzoni and Anne Duffy and Eva Grof and Bernd Ahrens and Anne Berghoefer and Bruno Mueller-Oerlinghausen and Martina Dvor{\'a}kov{\'a} and E Libigerov{\'a} and Milo{\vs} Vojtěchovsk{\'y} and Petr Zvolsky and A. A. Nilsson and Helena Prochazka and Rasmus Wentzer Licht and Niels Anton Rasmussen and Mogens Schou and Per Vestergaard and Anita Holzinger and Chris Schumann and Kenneth Thau and Guy Rouleau},
  journal={Molecular Psychiatry},
SIR — Over the last 3 years, a large number of studies have focused on a possible role of trinucleotide repeats, particularly expanded CAG/CTG repeats, in bipolar disorder (BD). The investigation of trinucleotide repeats has been supported by reports of genetic anticipation as well as studies using the repeat expansion detection (RED) technique. Recently, two independent studies have reported the presence of polyglutamine tracts in proteins of about 50–60 kDa extracted from lymphoblastoid cell… CONTINUE READING