Polyglutamine protein aggregates are dynamic

@article{Kim2002PolyglutaminePA,
  title={Polyglutamine protein aggregates are dynamic},
  author={Soojin Kim and Ellen A. A. Nollen and Kazunori Kitagawa and Vytautas P. Bindokas and Richard I. Morimoto},
  journal={Nature Cell Biology},
  year={2002},
  volume={4},
  pages={826-831}
}
Protein aggregation and the formation of inclusion bodies are hallmarks of the cytopathology of neurodegenerative diseases, including Huntington's disease, Amyotropic lateral sclerosis, Parkinson's disease and Alzheimer's disease. The cellular toxicity associated with protein aggregates has been suggested to result from the sequestration of essential proteins that are involved in key cellular events, such as transcription, maintenance of cell shape and motility, protein folding and protein… CONTINUE READING
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