Polyglutamine neurodegeneration: minding your Ps and Qs

  title={Polyglutamine neurodegeneration: minding your Ps and Qs},
  author={Henry L. Paulson},
  journal={Nature Medicine},
Most neurodegenerative disorders that afflict humans are caused, in part, by abnormal protein accumulation and aggregation1. Among these disorders, the polyglutamine diseases are particularly intriguing: at least nine inherited diseases result from CAG repeat mutations that encode abnormally long polyglutamine domains in otherwise unrelated disease proteins… CONTINUE READING