Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences

Abstract

Polyglutamine (polyQ) expansion in exon1 (XN1) of the huntingtin protein is linked to Huntington's disease. When the number of glutamines exceeds a threshold of approximately 36-40 repeats, XN1 can readily form amyloid aggregates similar to those associated with disease. Many experiments suggest that misfolding of monomeric XN1 plays an important role in… (More)
DOI: 10.1371/journal.pcbi.1000772

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@inproceedings{Lakhani2010PolyglutamineIM, title={Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences}, author={Vinal V. Lakhani and Zhengyou He and Nikolay V. Dokholyan}, booktitle={PLoS Computational Biology}, year={2010} }