Polyglutamine (PolyQ) diseases: genetics to treatments.

@article{Fan2014PolyglutamineD,
  title={Polyglutamine (PolyQ) diseases: genetics to treatments.},
  author={Hueng-Chuen Fan and Li-Ing Ho and Ching-Shiang Chi and Shyi-Jou Chen and Giia-Sheun Peng and Tzu-Min Chan and Shinn-Zong John Lin and Horng-Jyh Harn},
  journal={Cell transplantation},
  year={2014},
  volume={23 4-5},
  pages={
          441-58
        }
}
The polyglutamine (polyQ) diseases are a group of neurodegenerative disorders caused by expanded cytosine-adenine-guanine (CAG) repeats encoding a long polyQ tract in the respective proteins. To date, a total of nine polyQ disorders have been described: six spinocerebellar ataxias (SCA) types 1, 2, 6, 7, 17; Machado-Joseph disease (MJD/SCA3); Huntington's disease (HD); dentatorubral pallidoluysian atrophy (DRPLA); and spinal and bulbar muscular atrophy, X-linked 1 (SMAX1/SBMA). PolyQ diseases… CONTINUE READING

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