Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice.

@article{Chen2007PolygenicVF,
  title={Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice.},
  author={Hualan Chen and Rick A. Bright and Kanta Subbarao and Catherine Smith and Nancy J. Cox and Jacqueline M. Katz and Yumiko Matsuoka},
  journal={Virus research},
  year={2007},
  volume={128 1-2},
  pages={159-63}
}
Virulence factors of influenza A (H5N1) viruses collected in 1997 from mammalian hosts were examined using a BALB/c mouse model. Fifteen amino acid (aa) residues in four influenza virus genes which correlated with high- and low-pathogenic phenotypes in mice were identified by analyzing sequence alignments. In addition to these specific residues, the effects of aa residue 627 of the PB2 gene, and the hemagglutinin (HA) and neuraminidase (NA) genes were also investigated using a reverse genetics… CONTINUE READING
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