Polygenic variation and transmission factors involved in the resistance/susceptibility to scrapie in a Romanov flock.

@article{Diaz2005PolygenicVA,
  title={Polygenic variation and transmission factors involved in the resistance/susceptibility to scrapie in a Romanov flock.},
  author={Clara Diaz and Zulma G Vitezica and Rachel Rupp and Olivier Andr{\'e}oletti and Jean Michel Elsen},
  journal={The Journal of general virology},
  year={2005},
  volume={86 Pt 3},
  pages={849-57}
}
Data from 4049 Romanov sheep belonging to a flock affected by natural scrapie were analysed by using survival-analysis techniques. Failure time was defined as the period of time between first exposure to infection and the date that animals left the flock with scrapie signs. Four hundred and forty-seven sheep were identified as 'scrapie animals'. Several models, including level of exposure as a time-dependent effect, PrP genotype, sex, age at first exposure, litter size and factors related to… CONTINUE READING

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