Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

@inproceedings{Weiner2017PolygenicTD,
  title={Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders},
  author={Daniel J Weiner and Emilie M Wigdor and Stephan Ripke and Raymond K Walters and Jack A. Kosmicki and Jakob Grove and Kaitlin E. Samocha and Jacqueline I. Goldstein and Aysu Okbay and Jonas Bybjerg-Grauholm and Thomas M Werge and David Michael Hougaard and Jacob Taylor and David H. Skuse and Bernie J Devlin and Richard J. L. Anney and Stephan J. Sanders and Somer Bishop and Preben B Mortensen and Anders D. B\orglum and George Davey Smith and Mark J. Daly and Elise B. Robinson},
  booktitle={Nature Genetics},
  year={2017}
}
Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational… CONTINUE READING

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Analysis of protein-coding genetic variation in 60,706 humans

  • M Lek
  • 2016

Genome-wide association study identifies 74 loci associated with educational attainment

  • A Okbay
  • 2016

A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity? Biological psychiatry

  • P Chaste
  • 2015

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