Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants.

@article{Yang2013PolygenicTA,
  title={Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants.},
  author={Li Yang and Benjamin M. Neale and L Liu and Sang Hong Lee and Naomi R Wray and Ning Ji and Haimei Li and Qiu-jin Qian and Dongliang Wang and Jun Li and Stephen V Faraone and Yufeng Wang},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2013},
  volume={162B 5},
  pages={419-430}
}
Attention-deficit hyperactivity disorder (ADHD) is a complex polygenic disorder. This study aimed to discover common and rare DNA variants associated with ADHD in a large homogeneous Han Chinese ADHD case-control sample. The sample comprised 1,040 cases and 963 controls. All cases met DSM-IV ADHD diagnostic criteria. We used the Affymetrix6.0 array to assay both single nucleotide polymorphisms (SNPs) and copy number variants (CNVs). Genome-wide association analyses were performed using PLINK… CONTINUE READING
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