Polygenic scores via penalized regression on summary statistics.

  title={Polygenic scores via penalized regression on summary statistics.},
  author={Timothy Shin Heng Mak and Robert Milan Porsch and Shing Wan Choi and Xueya Zhou and Pak C. Sham},
  journal={Genetic epidemiology},
  volume={41 6},
Polygenic scores (PGS) summarize the genetic contribution of a person's genotype to a disease or phenotype. They can be used to group participants into different risk categories for diseases, and are also used as covariates in epidemiological analyses. A number of possible ways of calculating PGS have been proposed, and recently there is much interest in… CONTINUE READING