Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

@article{Power2015PolygenicRS,
  title={Polygenic risk scores for schizophrenia and bipolar disorder predict creativity},
  author={Robert A. Power and Stacy Steinberg and Gyda Bjornsdottir and Cornelius A. Rietveld and Abdel Abdellaoui and Michel Nivard and Magnus Johannesson and Tessel E. Galesloot and Jouke- Jan Hottenga and Gonneke Willemsen and David Cesarini and Daniel J. Benjamin and Patrik K. E. Magnusson and Fredrik Ull{\'e}n and Henning Tiemeier and Albert Hofman and Frank J. A. van Rooij and G. Bragi Walters and Engilbert Sigurdsson and Thorgeir E. Thorgeirsson and Andr{\'e}s Ingason and Agnar Helgason and Augustine Kong and Lambertus A. Kiemeney and Philipp D. Koellinger and Dorret I. Boomsma and Daniel Fannar Gudbjartsson and Hreinn Stef{\'a}nsson and K{\'a}ri Stef{\'a}nsson},
  journal={Nature Neuroscience},
  year={2015},
  volume={18},
  pages={953-955}
}
We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10−6 and 3.8 × 10−6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and… Expand
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