Polygenic risk for schizophrenia associated with working memory-related prefrontal brain activation in patients with schizophrenia and healthy controls.

@article{Kauppi2015PolygenicRF,
  title={Polygenic risk for schizophrenia associated with working memory-related prefrontal brain activation in patients with schizophrenia and healthy controls.},
  author={Karolina Kauppi and Lars T. Westlye and Martin S Tesli and Francesco Bettella and Christine Lycke Brandt and Morten Mattingsdal and Torill Ueland and Thomas Espeseth and Ingrid Agartz and Ingrid Melle and Srdjan Djurovic and Ole A. Andreassen},
  journal={Schizophrenia bulletin},
  year={2015},
  volume={41 3},
  pages={736-43}
}
Schizophrenia is a highly heritable and polygenic disease, and identified common genetic variants have shown weak individual effects. Many studies have reported altered working memory (WM)-related brain activation in schizophrenia, preferentially in the frontal lobe. Such differences in brain activations could reflect inherited alterations possibly involved in the disease etiology, or rather secondary disease-related mechanisms. The use of polygenic risk scores (PGRS) based on a large number of… CONTINUE READING
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