Polygenic risk for Alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people.


Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non… (More)
DOI: 10.3233/JAD-131058


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