Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study.

@article{Belsky2013PolygenicRA,
  title={Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study.},
  author={Daniel W Belsky and Terrie E Moffitt and Timothy B. Baker and Andrea K. Biddle and J. Paul O. Evans and Honalee Harrington and Renate M. Houts and Madeline H Meier and Karen Sugden and Benjamin S. Williams and Richie G. Poulton and Avshalom Caspi},
  journal={JAMA psychiatry},
  year={2013},
  volume={70 5},
  pages={534-42}
}
IMPORTANCE Genome-wide hypothesis-free discovery methods have identified loci that are associated with heavy smoking in adulthood. Research is needed to understand developmental processes that link newly discovered genetic risks with adult heavy smoking. OBJECTIVE To test how genetic risks discovered in genome-wide association studies of adult smoking influence the developmental progression of smoking behavior from initiation through conversion to daily smoking, progression to heavy smoking… CONTINUE READING
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