Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.

@article{Andersen2017PolygenicSF,
  title={Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.},
  author={Allan M Andersen and R. H. Pietrzak and Henry R. Kranzler and Li Ma and Hang Zhou and Xiaoming Liu and John R. Kramer and Samuel Kuperman and Howard J. Edenberg and John J I Nurnberger and John P. Rice and Jay A. Tischfield and Alison M. Goate and Tatiana Foroud and Jacquelyn Leigh Meyers and Bernice Porjesz and Danielle M Dick and Victor M. Hesselbrock and Eric Boerwinkle and Steven M. Southwick and John H. Krystal and Myrna M. Weissman and Douglas F. Levinson and James B. Potash and Joel Gelernter and Shizhong Han},
  journal={JAMA psychiatry},
  year={2017},
  volume={74 11},
  pages={
          1153-1160
        }
}
Importance Major depressive disorder (MDD) and alcohol dependence (AD) are heritable disorders with significant public health burdens, and they are frequently comorbid. Common genetic factors that influence the co-occurrence of MDD and AD have been sought in family, twin, and adoption studies, and results to date have been promising but inconclusive. Objective To examine whether AD and MDD overlap genetically, using a polygenic score approach. Design, Settings, and Participants Association… CONTINUE READING
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