Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes

@inproceedings{Allen2010PolygenicRV,
  title={Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes},
  author={Hana Lango Allen and Stefan B. Johansson and Sian Ellard and Beverley M Shields and Jens Kristoffer Hertel and Helge R{\ae}der and Kevin Colclough and Anders Molven and Timothy M. Frayling and P{\aa}l R. Nj\olstad and Andrew T Hattersley and M. N. Weedon},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE Mutations in the HNF1A gene are the most common cause of maturity-onset diabetes of the young (MODY). There is a substantial variation in the age at diabetes diagnosis, even within families where diabetes is caused by the same mutation. We investigated the hypothesis that common polygenic variants that predispose to type 2 diabetes might account for the difference in age at diagnosis. RESEARCH DESIGN AND METHODS Fifteen robustly associated type 2 diabetes variants were successfully… CONTINUE READING
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