Polygenic Analysis of Late-Onset Alzheimer’s Disease from Mainland China

  title={Polygenic Analysis of Late-Onset Alzheimer’s Disease from Mainland China},
  author={Bin Jiao and Xiao-yan Liu and Lin Zhou and Maggie Haitian Wang and Yafang Zhou and Tingting Xiao and Weiwei Zhang and Rui Sun and Mary Miu Yee Waye and Beisha Tang and L i Sh{\'e}n and Riqiang Yan},
  booktitle={PloS one},
Recently, a number of single nucleotide polymorphisms (SNPs) were identified to be associated with late-onset Alzheimer disease (LOAD) through genome-wide association study data. Identification of SNP-SNP interaction played an important role in better understanding genetic basis of LOAD. In this study, fifty-eight SNPs were screened in a cohort of 229 LOAD cases and 318 controls from mainland China, and their interaction was evaluated by a series of analysis methods. Seven risk SNPs and six… CONTINUE READING
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