Polygenes and Oligogenes

@article{Waddington1943PolygenesAO,
  title={Polygenes and Oligogenes},
  author={C. H. Waddington},
  journal={Nature},
  year={1943},
  volume={151},
  pages={394-394}
}
IN a recent communication1, I suggested that we can consider embryonic development in terms of two types of process; on one hand, processes which ‘switch’ the developing tissues into some one of a number of alternative paths, and on the other hand, the ‘buffering’ processes by which those paths are defined. Mather2 afterwards attempted to develop this idea by identifying the genes which act in a buffering manner with his so-called ‘polygenes’ and the genes acting by switch mechanisms with… CONTINUE READING

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