Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site.


Bioassay-guided fractionation was used to isolate the lignan polygamain as the microtubule-active constituent in the crude extract of the Mountain torchwood, Amyris madrensis. Similar to the effects of the crude plant extract, polygamain caused dose-dependent loss of cellular microtubules and the formation of aberrant mitotic spindles that led to G(2)/M… (More)
DOI: 10.1124/mol.111.075838


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