Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination

@article{Lewinsohn2017PolyfunctionalCT,
  title={Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination},
  author={David M Lewinsohn and Thomas J. Scriba},
  journal={Frontiers in Immunology},
  year={2017},
  volume={8}
}
  • David M Lewinsohn, David M Lewinsohn, Thomas J. Scriba
  • Published 2017
  • Biology, Medicine
  • Frontiers in Immunology
  • Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of morbidity and mortality worldwide, despite the widespread use of the only licensed vaccine, Bacille Calmette Guerin (BCG). Eradication of TB will require a more effective vaccine, yet evaluation of new vaccine candidates is hampered by lack of defined correlates of protection. Animal and human studies of intracellular pathogens have extensively evaluated polyfunctional CD4+ T cells producing multiple pro… CONTINUE READING

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