Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung.

@article{Gnther2011PolyethyleniminesFR,
  title={Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung.},
  author={Melanie G{\"u}nther and Jens Lipka and Anastasia Malek and Daniela Gutsch and Wolfgang G Kreyling and Achim Aigner},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2011},
  volume={77 3},
  pages={438-49}
}
RNA interference (RNAi) is a promising strategy to inhibit the expression of pathologically relevant genes, which show aberrant (over-)expression, e.g. in tumors or other pathologies. The induction of RNAi relies on small interfering RNAs (siRNAs), which trigger the specific mRNA degradation. Their instability and poor delivery into target tissues including… CONTINUE READING