Polyethylenimine-based antisense oligodeoxynucleotides of IL-4 suppress the production of IL-4 in a murine model of airway inflammation.

@article{Seong2006PolyethyleniminebasedAO,
  title={Polyethylenimine-based antisense oligodeoxynucleotides of IL-4 suppress the production of IL-4 in a murine model of airway inflammation.},
  author={J Y Seong and Kyung-Mi Lee and Sung Tae Kim and Su-Eon Jin and C K Kim},
  journal={The journal of gene medicine},
  year={2006},
  volume={8 3},
  pages={314-23}
}
BACKGROUND Interleukin-4 (IL-4) plays a crucial role as an inflammatory mediator in allergic asthma via inducing Th2 inflammation and IgE synthesis. To develop an effective therapeutic agent which specifically inhibits production of IL-4, antisense oligodeoxynucleotides (AS-ODNs) against murine IL-4 mRNA were generated and complexed with polyethylenimine (PEI) to improve intracellular delivery. METHODS AS-ODNs were generated against the translation initiation region of murine IL-4 mRNA, and… CONTINUE READING

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