Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens.

Abstract

Polyethyleneimine (PEI) is an organic polycation used extensively as a gene and DNA vaccine delivery reagent. Although the DNA targeting activity of PEI is well documented, its immune activating activity is not. We recently reported that PEI has robust mucosal adjuvanticity when administered intranasally with glycoprotein antigens. Here, we show that PEI… (More)
DOI: 10.1093/intimm/dxu055

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