Polyethyleneimine-based core-shell nanogels: a promising siRNA carrier for argininosuccinate synthetase mRNA knockdown in HeLa cells.

@article{Mimi2012PolyethyleneiminebasedCN,
  title={Polyethyleneimine-based core-shell nanogels: a promising siRNA carrier for argininosuccinate synthetase mRNA knockdown in HeLa cells.},
  author={Hetti Mimi and Kin Man Ho and Yuen Shan Siu and Aihua Wu and Pei Li},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={158 1},
  pages={123-30}
}
RNA interference using small interfering RNA (siRNA) is a promising biological strategy for treatment of diverse diseases; however, application of siRNA is severely hindered by its poor stability and low cellular uptake efficiency. We have recently demonstrated that polyethyleneimine (PEI)-based amphiphilic core-shell particles have several distinguishing advantages over native PEI and its derivatives. This paper presents a novel type of PEI-based nanogels with a biodegradable gelatin core. The… CONTINUE READING
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