Polyethylene glycol-modified arachidyl chitosan-based nanoparticles for prolonged blood circulation of doxorubicin.

@article{Termsarasab2014PolyethyleneGA,
  title={Polyethylene glycol-modified arachidyl chitosan-based nanoparticles for prolonged blood circulation of doxorubicin.},
  author={Ubonvan Termsarasab and In-Soo Yoon and Ju-Hwan Park and Hyun Tae Moon and Hyun-Jong Cho and Dae-Duk Kim},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={464 1-2},
  pages={127-34}
}
Doxorubicin (DOX)-loaded nanoparticles based on polyethylene glycol-conjugated chitosan oligosaccharide-arachidic acid (CSOAA-PEG) were explored for potential application to leukemia therapy. PEG was conjugated with CSOAA backbone via amide bond formation and the final product was verified by (1)H NMR analysis. Using the synthesized CSOAA-PEG, nanoparticles having characteristics of a 166-nm mean diameter, positive zeta potential, and spherical shape were produced for the delivery of DOX. The… CONTINUE READING
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