Polyethylene glycol-liposomal doxorubicin: a review of its use in the management of solid and haematological malignancies and AIDS-related Kaposi's sarcoma.

@article{Sharpe2002PolyethyleneGD,
  title={Polyethylene glycol-liposomal doxorubicin: a review of its use in the management of solid and haematological malignancies and AIDS-related Kaposi's sarcoma.},
  author={Miriam L Sharpe and Stephanie E. Easthope and Gillian M. Keating and Harriet M. Lamb},
  journal={Drugs},
  year={2002},
  volume={62 14},
  pages={2089-126}
}
UNLABELLED Polyethylene glycol (PEG)-liposomal doxorubicin is a formulation of the anthracycline doxorubicin in which the drug is encapsulated in PEG-coated liposomes. This alters the pharmacokinetic properties of doxorubicin, prolonging circulation time and enhancing localisation to tumours. In a large randomised trial, intravenous PEG-liposomal doxorubicin was at least as effective as topotecan in patients with ovarian cancer refractory or sensitive to first-line platinum-based chemotherapy… CONTINUE READING
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