Polyethylene glycol improves function and reduces oxidative stress in synaptosomal preparations following spinal cord injury.

@article{Luo2004PolyethyleneGI,
  title={Polyethylene glycol improves function and reduces oxidative stress in synaptosomal preparations following spinal cord injury.},
  author={Jian Luo and Richard Ben Borgens and Riyi Shi},
  journal={Journal of neurotrauma},
  year={2004},
  volume={21 8},
  pages={
          994-1007
        }
}
Spinal cord injury (SCI) results in rapid and significant oxidative stress. We have previously demonstrated that administration of polyethylene glycol (PEG) inhibits oxidative stress using an in vitro model of SCI. In this study we tested the effects of PEG in vivo, to elucidate the mechanism of PEG-mediated neuroprotection. We show that a compression injury at T10-11 induced diffusive oxidative stress in crude synaptosomal preparations, correlated with synaptosomal dysfunction and increased… CONTINUE READING
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