Polyethylene Glycol Density and Length Affects Nanoparticle Uptake by Cancer Cells

@inproceedings{Chithrani2014PolyethyleneGD,
  title={Polyethylene Glycol Density and Length Affects Nanoparticle Uptake by Cancer Cells},
  author={Devika B. Chithrani and Devika Basnagge Chithrani},
  year={2014}
}
The prospective cancer therapy applications of inorganic nanoparticles (NPs) have been encouraged by surface modifications with polyethylene glycol (PEG). When grafted at high densities, PEG reduces NP surface interaction with its environment, hence minimizing its detection by the immune system. The drawback of high density PEG surfaces is its reduced uptake by cancer cells. This is disadvantageous for applications that favor intracellular localization of such NPs. On the other hand, reduced… CONTINUE READING

Figures and Tables from this paper.

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Impact of silica nanoparticle surface chemistry on protein corona formation and consequential interactions with biological cells.

  • Materials science & engineering. C, Materials for biological applications
  • 2017
VIEW 16 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

Size-dependent tissue kinetics of PEG-coated gold nanoparticles.

  • Toxicology and applied pharmacology
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

889-896

M Liong, J Lu, +5 authors 25 drug delivery. ACS Nano
  • Figure 6: NPs in MDA-MB-231 cells and corresponding quantification data. There is general agreement between the observed number of fluorescent particles and measured gold concentration. Polyethylene Glycol Density and Length Affects Nanoparticle Uptake by Cancer Cells Citation: Cruje C, Chithrani
  • 2014
VIEW 1 EXCERPT

Applications of nanoparticles in nanomedicine.

  • Journal of biomedical nanotechnology
  • 2014
VIEW 3 EXCERPTS