Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation.

@article{Jess2002PolyesterDS,
  title={Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation.},
  author={Omayra L Padilla De Jes{\'u}s and Henrik R Ihre and Lucie Gagne and Jean M. J. Fr{\'e}chet and Francis C. Szoka},
  journal={Bioconjugate chemistry},
  year={2002},
  volume={13 3},
  pages={453-61}
}
High molecular weight polymers (> 20 000 Da) have been widely used as soluble drug carriers to improve drug targeting and therapeutic efficacy. Dendritic polymers are exceptional candidates for the preparation of near monodisperse drug carriers due to their well-defined structure, multivalency, and flexibility for tailored functionalization. We evaluated various dendritic architectures composed of a polyester dendritic scaffold based on the monomer unit 2,2-bis(hydroxymethyl)propanoic acid for… CONTINUE READING

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