Polyester dendritic systems for drug delivery applications: design, synthesis, and characterization.

@article{Ihre2002PolyesterDS,
  title={Polyester dendritic systems for drug delivery applications: design, synthesis, and characterization.},
  author={Henrik R Ihre and Omayra L Padilla De Jes{\'u}s and Francis C. Szoka and Jean M. J. Fr{\'e}chet},
  journal={Bioconjugate chemistry},
  year={2002},
  volume={13 3},
  pages={443-52}
}
Attachment of drugs to high molecular weight polymers can significantly improve both tumor targeting and therapeutic efficacy due to the enhanced permeability and retention effect observed in tumor tissue. However, the commercial availability of well-defined water-soluble polymeric systems with narrow polydispersities that are biocompatible, nontoxic, and nonimmunogenic is rather limited. To address this need, we have investigated dendritic polymers as promising scaffolds for the preparation of… CONTINUE READING
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