Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes.

Abstract

Taxanes are potent antimitotic agents that have demonstrated efficacy in a wide range of malignancies. Due to their poor water-solubility, these cytostatic drugs were first formulated with low molecular weight surfactants, e.g. Cremophor EL (CrEL) and Tween 80 (polysorbate 80), which are known to exhibit serious adverse effects in humans. In recent years… (More)
DOI: 10.1016/j.jconrel.2009.11.012

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Cite this paper

@article{Gaucher2010PolyesterbasedMA, title={Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes.}, author={Genevi{\`e}ve Gaucher and Robert H. Marchessault and Jean-Christophe Leroux}, journal={Journal of controlled release : official journal of the Controlled Release Society}, year={2010}, volume={143 1}, pages={2-12} }