Polyenoic very-long-chain fatty acids mobilize intracellular calcium from a thapsigargin-insensitive pool in human neutrophils. The relationship between Ca2+ mobilization and superoxide production induced by long- and very-long-chain fatty acids.

@article{Hardy1995PolyenoicVF,
  title={Polyenoic very-long-chain fatty acids mobilize intracellular calcium from a thapsigargin-insensitive pool in human neutrophils. The relationship between Ca2+ mobilization and superoxide production induced by long- and very-long-chain fatty acids.},
  author={Stephen J. Hardy and Brenton S. Robinson and Antonio Ferrante and Charles S. T. Hii and David W Johnson and A. Andriko Poulos and Andrew W. Murray},
  journal={The Biochemical journal},
  year={1995},
  volume={311 ( Pt 2)},
  pages={
          689-97
        }
}
Fatty acids with more than 22 carbon atoms (very-long-chain fatty acids; VLCFAs) are normal cellular components that have been implicated in the pathophysiology of a number of peroxisomal disorders. To date, however, essentially nothing is known regarding their biological activities. Ca2+ mobilization is an important intracellular signalling system for a variety of agonists and cell types. Given that several polyunsaturated long-chain fatty acids mobilize intracellular Ca2+ and that we have… CONTINUE READING
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