Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress.

@article{Okiyama2009PolyenephosphatidylcholinePA,
  title={Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress.},
  author={Wataru Okiyama and Naoki Tanaka and Tamie Nakajima and Eiji Tanaka and Kendo Kiyosawa and Frank J. Gonzalez and Toshifumi Aoyama},
  journal={Journal of hepatology},
  year={2009},
  volume={50 6},
  pages={1236-46}
}
BACKGROUND/AIMS Alcoholic liver disease (ALD) is one of the leading causes of cirrhosis and yet efficient therapeutic strategies are lacking. Polyenephosphatidylcholine (PPC), a major component of essential phospholipids, prevented alcoholic liver fibrosis in baboons, but its precise mechanism remains uncertain. We aimed to explore the effects of PPC on ALD using ethanol-fed peroxisome proliferator-activated receptor alpha (Ppara)-null mice, showing several similarities to human ALD. METHODS… CONTINUE READING