Polyelectrolyte multilayers fabricated from antifungal β-peptides: design of surfaces that exhibit antifungal activity against Candida albicans.

@article{Karlsson2010PolyelectrolyteMF,
  title={Polyelectrolyte multilayers fabricated from antifungal β-peptides: design of surfaces that exhibit antifungal activity against Candida albicans.},
  author={Amy J Karlsson and Ryan M Flessner and Samuel H. Gellman and David M Lynn and Sean P Palecek},
  journal={Biomacromolecules},
  year={2010},
  volume={11 9},
  pages={2321-8}
}
The fungal pathogen Candida albicans can form biofilms on the surfaces of medical devices that are resistant to drug treatment and provide a reservoir for recurrent infections. The use of fungicidal or fungistatic materials to fabricate or coat the surfaces of medical devices has the potential to reduce or eliminate the incidence of biofilm-associated infections. Here we report on (i) the fabrication of multilayered polyelectrolyte thin films (PEMs) that promote the surface-mediated release of… CONTINUE READING
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