Polyelectrolyte microcapsules with entrapped multicellular tumor spheroids as a novel tool to study the effects of photodynamic therapy.

@article{ZaytsevaZotova2011PolyelectrolyteMW,
  title={Polyelectrolyte microcapsules with entrapped multicellular tumor spheroids as a novel tool to study the effects of photodynamic therapy.},
  author={Daria S Zaytseva-Zotova and Olga O Udartseva and Elena R Andreeva and Artur Bartkowiak and Lina N Bezdetnaya and François Guillemin and Jean-Louis Goergen and Elena A Markvicheva},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2011},
  volume={97 2},
  pages={255-62}
}
In the current study, semi-permeable alginate-oligochitosan microcapsules for multicellular tumor spheroids (MTS) generation were elaborated and tested, to estimate a response of the microencapsulated MTS (MMTS) to photodynamic therapy (PDT). The microcapsules (mean diameter 600 μm) with entrapped human breast adenocarcinoma MCF-7 cells were obtained using an electrostatic bead generator, and MMTS were generated by in vitro long-term cell cultivation. The formed MMTS were incubated in Chlorin… CONTINUE READING
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