Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy.

@article{Black2013PolydopamineenabledSF,
  title={Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy.},
  author={Kvar Carl Lee Black and Ji Yi and Jos{\'e} Guiti{\'a}n Rivera and Daria Cecylia Zelasko-Leon and Phillip B Messersmith},
  journal={Nanomedicine},
  year={2013},
  volume={8 1},
  pages={
          17-28
        }
}
AIM A novel biomimetic strategy was employed for presenting antibodies on gold nanorods (NRs) to target growth factor receptors on cancer cells for use in photothermal therapy. MATERIALS & METHODS Polydopamine (PD) was polymerized onto gold NRs, and EGF receptor antibodies (anti-EGFR) were immobilized onto the layer. Cell-binding affinity and light-activated cell death of cancer cells incubated with anti-EGFR-PD-NRs were quantified by optical imaging. RESULTS PD was deposited onto gold NRs… CONTINUE READING
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