Polydextrose changes the gut microbiome and attenuates fasting triglyceride and cholesterol levels in Western diet fed mice

@article{Raza2017PolydextroseCT,
  title={Polydextrose changes the gut microbiome and attenuates fasting triglyceride and cholesterol levels in Western diet fed mice},
  author={Ghulam Shere Raza and Heli Putaala and Ashley A. Hibberd and Esa Alhoniemi and Kirsti Tiihonen and Kari Antero M{\"a}kel{\"a} and Karl-Heinz Herzig},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
Obesity and dyslipidemia are hallmarks of metabolic and cardiovascular diseases. Polydextrose (PDX), a soluble fiber has lipid lowering effects. We hypothesize that PDX reduces triglycerides and cholesterol by influencing gut microbiota, which in turn modulate intestinal gene expression. C57BL/6 male mice were fed a Western diet (WD) ±75 mg PDX twice daily by oral gavage for 14 days. Body weight and food intake were monitored daily. Fasting plasma lipids, caecal microbiota and gene expression… 

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