Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease.

@article{Bitto2008PolydeoxyribonucleotideR,
  title={Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease.},
  author={Alessandra Bitto and Francesca Polito and Domenica Altavilla and Letteria Minutoli and Alba Migliorato and Francesco Squadrito},
  journal={Journal of vascular surgery},
  year={2008},
  volume={48 5},
  pages={1292-300}
}
OBJECTIVE This study investigated whether polydeoxyribonucleotide (PDRN) may be efficacious in the treatment of peripheral artery occlusive diseases, which are a major cause of morbidity in Western countries and still lack standardized treatment. METHODS We investigated the effects of PDRN, a mixture of deoxyribonucleotides, in an experimental model of hind limb ischemia (HLI) in rats to stimulate vascular endothelial growth factor (VEGF)-A production and to avoid critical ischemia. The… CONTINUE READING
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