Polydactyly in Mice

  title={Polydactyly in Mice},
  author={Rory A. Fisher},
  • R. Fisher
  • Published 11 March 1950
  • Biology
  • Nature
THE genetics of polydactyly have attracted attention in a good many organisms, and in mice the pioneer researches of Fortuyn1, Murray2 and others have sufficed to reveal a situation of more than ordinary complexity. The first substantial step towards bringing the problem within reach of experimental elucidation was taken by Holt3 at the Galton Laboratory at University College, London, who demonstrated that by systematic selection a strain could be constructed manifesting polydactyly in nearly… 

The linkage of polydactyly with leaden in the house-mouse

It follows from Holt's work that in most of the occurrences of polydactyly studied in the literature, the situation has been much obscured by suppressors of varying intensity, so that no single-factor segregation has been observed, and that clear results will only be obtained by the use of stocks in which such suppressors have been largely eliminated.

Pulmonary Tumours and Group VII in the House-Mouse

The inheritance of susceptibility to pulmonary tumours in mice is multifactorial in nature and therefore the further investigation of this problem requires an approach designed to take this into account, and the experiment reported by Dr. Tatchell does not appear to do so.

A balanced four-point linkage experiment for linkage group XIII of the house mouse

Polydactylous mice have appeared in numerous stocks for some years, but was of very poor manifestation, and was not usable as a genetic factor until Ho]t (194.5) had selected for good manifestation after outcrossing.

Interaction of modifiers: The effect of pallid and fidget on polydactyly in the mouse

Interaction of modifiers: The effect of pallid and fidget on polydactyly in the mouse

Pulmonary Tumours and Group VII in the House-Mouse

THE points raised by Dr. Bloom were either fully covered in my communication or else were unsuitable for inclusion in a preliminary account.

Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications

This review has highlighted recent studies on the use of small molecules and drugs to manipulate histone signals to regulate chondrocyte functions or treat cartilage lesions, in particular osteoarthritis (OA), and discussed their potential therapeutic benefits and limitations.

A case of polydactyly with multiple thresholds in the mouse

A spontaneous occurrence of polydactyly in mice failed to comply with any acceptable segregation ratio, but its genetic basis was established by its rapid response to selection, and complex interactions between systemic and local influences on digit number were revealed, with implications for the gene control of limb development.