Polycythemic mice--an appropriate model for investigation of granulopoiesis.


In posthypoxic polycythemic mice (P) expanded granulopoiesis was found. After aplasia induced by a sublethal dose of cyclophosphamide (Cy), more granulocytic cells both in the bone marrow and spleen were found in P than in normal (N) mice treated in the same way. Spontaneous regeneration of granulocytic precursors during the first three days after Cy was… (More)